Syringaldehyde

134-96-3

C9H10O4

10 mM in DMSO

Immunology/Inflammation

Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis^[1]. Syringaldehyde moderately inhibits COX-2 activity with an IC₅₀ of 3.5 ug/mL^[2]. Anti-hyperglycemic and anti-inflammatory activities^[1]. In Vitro: Syringaldehyde inhibits COX-2 activity in a dosedependent manner with an IC₅₀ of 3.5 ug/mL^[2]. In Vivo: Syringaldehyde exerts anti-hyperglycemic effect in rat model of diabetes induced by streptozotocin. Apart from antioxidant capability, Syringaldehyde also has anti-inflammatory activity as it is found to have inhibitory action on cyclo-oxygenase 2 (COX-2) in mouse macrophage cell line^[1].