Ganoderic acid D

108340-60-9

514.65

DMSO : 100 mg/mL (194.31 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)

Apoptosis; Epigenetics; Cell Cycle/DNA Damage

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells^[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis^[3]. IC50 & Target: SIRT3^[1] In Vitro: Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC₅₀ of 17.3 mM^[2]. Ganoderic acid D (1-50 uM; 24-72 hours) reduces the cell survival rate in a dose- and time-dependent manner^[3].
Ganoderic acid D (10, 50 uM; 24, 48 hours) induces G2/M phase arrest^[3].
Ganoderic acid D (10, 50 uM; 24, 48 hours) induces a morphological change typical of apoptosis in HeLa cells^[3].
Ganoderic acid D (10 uM; 48 hours) up-regulates 14-3-3E and PRDX3^[3].