A-205804

251992-66-2

300.40

DMSO : 125 mg/mL (416.11 mM; Need ultrasonic)

Cytoskeleton

A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC₅₀ of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases^[1]. IC50 & Target: IC50: 20 nM (E-selectin), 25 nM (ICAM-1)^[1] In Vitro: A-205804 exhibits Cellular Toxicities for HUVEC with an IC₅₀ of 152 uM^[1].
A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system^[1].
In Vivo: A-205804 (5 mg/kg; p.o.) shows a half-life of 1 hour for rat^[1].
A-205804 (10 mg/kg; p.o.; 3 times per week; for 2 weeks) attenuates the E-selectin expression on the endothelial vascular niche cells in mice^[2].