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Tomatine

Tomatine

Item no.	CS-0019466-20mg
Manufacturer	ChemScene
Amount	20mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	17406-45-0
Similar products	17406-45-0
Available
Alternative Names	alpha-Tomatine; Lycopersicin; Tomatin
CAS	17406-45-0
Purity	>98%
MWt	1034.19
Formula	C50H83NO21
Solubility	DMSO : 250 mg/mL (241.74 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Proteasome
Biological Activity	Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity^[1]. In Vitro: Tomatine inhibits gastric carcinoma cell line (AGS), neuroblastoma cell line (SH-SY5Y) and non-small cell lung cancer cell line (A549) with IC₅₀s of 2 uM, 1.6 uM and 1.1 uM, respectively^[1].
Research Area	Neurological Disease

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Amount: 20mg

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