Rp-cAMPS (triethylammonium salt)

151837-09-1

446.46

10 mM in DMSO

Stem Cell/Wnt; Protein Tyrosine Kinase/RTK

Rp-cAMPS triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 uM and 4.5 uM, respectively) antagonist. Rp-cAMPS triethylammonium salt is resistant to hydrolysis by phosphodiesterases^{[1][2][3][4][5][6]}. IC50 & Target: Ki: 6.05 uM (PKA I) and 9.75 uM (PKA II)^[1] In Vitro: A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission^[2]. In Vivo: Rp-cAMPS (10 uM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons^[2].