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2-Iodomelatonin

2-Iodomelatonin

Item no.	CS-0020946-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Metabolism Glucose Homeostasis Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	93515-00-5
Similar products	93515-00-5
Available
CAS	93515-00-5
Purity	>98%
MWt	358.17
Formula	C13H15IN2O2
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	GPCR/G Protein; Neuronal Signaling
Target	Melatonin Receptor; Melatonin Receptor
Biological Activity	2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a K_i value of 28 pM, it is more 5-fold selective for MT₁ over MT₂^[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues^[1]. In Vitro: 2-iodomelatonin (0-7.5 uM; 18 hours) shares the protective properties of melatonin, it inhibits cell death of mutant htt ST14A and inhibits the increase in Rip2 expression in stressed mutant htt ST14A cells^[2].
Research Area	Cancer

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Amount: 5mg

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