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AMG-176

AMG-176

Item no.	CS-0021721-1mg
Manufacturer	ChemScene
Amount	1mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1883727-34-1
Available
CAS	1883727-34-1
Purity	>98%
Formula	C33H41ClN2O5S
MWt	613.21
Solubility	DMSO : 62.5 mg/mL (101.92 mM; Need ultrasonic)
Clinical Information	Phase 1
Pathway	Apoptosis
Target	Bcl-2 Family
Biological Activity	AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a K_i of 0.13 nM. IC50 & Target: Ki: 0.13 nM (MCL1)^[1]^[2]. In Vitro: AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (K_i=0.13 nM), with potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells^[1]^[2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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