β-Elemonic acid

28282-25-9

454.68

H2O : < 0.1 mg/mL (insoluble); DMSO : 100 mg/mL (219.93 mM; Need ultrasonic)

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-kappaB; Immunology/Inflammation

beta-Elemonic acid is a triterpene isolated from Boswellia papyrifera. beta-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. beta-Elemonic acid exhibits anticancer and anti-inflammatory effects^[1][2]. In Vitro: beta-elemonic acid (1, 3, 10, 20 uM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner^[1].
beta-elemonic acid (1, 3, 10, 20 uM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC₅₀ value following a 24-h exposure to beta-elemonic acid was 6.92 uM^[1].
beta-elemonic acid (20 uM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase^[1].
beta-elemonic acid (1, 3, 10, 20 uM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells^[1].