BF 227

Item no.	CS-0025505-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	845647-80-5
Similar products	845647-80-5
Available
CAS	845647-80-5
Purity	>98%
MWt	333.38
Formula	C16H16FN3O2S
Solubility	DMSO : 62.5 mg/mL (187.47 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Neuronal Signaling
Target	Amyloid-beta
Biological Activity	BF 227 is a candidate for an amyloid imaging probe for PET, with a K_i of 4.3 nM for Abeta1-42 fibrils. IC50 & Target: Ki: 4.3 nM (Abeta1-42)^[1]. In Vitro: BF-227 has a high binding affinity for Abeta1-42 fibrils. The K_i value for Abeta1-42 fibrils in competitive binding assay using [¹²⁵I]BF-180 is 4.3+/-1.3 nM in BF-227 (K_d value of [¹²⁵I]BF-180: 10.8+/-1.5 nM)_[1]. [¹¹C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD^[2].
Research Area	Neurological Disease

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