Statil

Item no.	CS-0026367-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	72702-95-5
Similar products	72702-95-5
Available
Alternative Names	Ponalrestat
CAS	72702-95-5
Purity	>98%
MWt	391.19
Formula	C17H12BrFN2O3
Solubility	DMSO : 62.5 mg/mL (159.77 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Aldose Reductase
Biological Activity	Statil (Ponalrestat) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Statil selectively inhibits ALR2 (K_i=7.7 nM) over ALR1 (K_i=60 uM). Statil inhibits the conversion of glucose to sorbitol^[1]^[2]^[3]. IC50 & Target: Ki: 7.7 nM (ALR2) and 60 uM (ALR1)^[1] In Vitro: Statil (Ponalrestat; 1, 10, 100 uM; 6 hours) reduces PGF2alphaproduction in response to IL-1 in both cultured endometrial cells and endometrial explants^[2]. In Vivo: Statil (Ponalrestat; 10, 50 mg/kg; orally; daily; 8 weeks) reduces sorbitol accumulation indicating efficacy of aldose reductase inhibition^[3].
Research Area	Metabolic Disease

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