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Paxilline

Paxilline

Item no.	CS-0026740-10mg
Manufacturer	ChemScene
CASRN	57186-25-1
Amount	10mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	57186-25-1
Similar products	57186-25-1
Available
CAS	57186-25-1
Purity	>98%
MWt	435.56
Formula	C27H33NO4
Solubility	DMSO : 100 mg/mL (229.59 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Membrane Transporter/Ion Channel; Membrane Transporter/Ion Channel; Neuronal Signaling
Target	Calcium Channel; Potassium Channel; Calcium Channel
Biological Activity	Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) with IC₅₀s between 5 uM and 50 uM for differing isoforms. Paxilline possesses significant anticonvulsant activity^[1]^[2]^[3]. IC50 & Target: IC50: 5-50 uM (SERCA)^[2], BK channel^[1]
Research Area	Neurological Disease

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Amount: 10mg

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