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AZD5423

AZD5423

Item no.	CS-0027671-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1034148-04-3
Similar products	1034148-04-3
Available
CAS	1034148-04-3
Purity	>98%
MWt	487.45
Formula	C25H21F4N3O3
Solubility	DMSO : 250 mg/mL (512.87 mM; Need ultrasonic)
Clinical Information	Phase 2
Pathway	GPCR/G Protein
Target	Glucocorticoid Receptor
Biological Activity	AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM)^[1]. AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma^[2]. IC50 & Target: Glucocorticoid receptor^[1] In Vitro: The affinity of AZD5423 to the glucocorticoid receptor is high with an IC₅₀ of 0.9 nM in a radioligand human glucocorticoid receptor assay, and selectivity towards other steroid hormone receptors is >900-fold^[1].
Research Area	Inflammation/Immunology; Endocrinology

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