Eact

Item no.	CS-0027763-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	461000-66-8
Similar products	461000-66-8
Available
CAS	461000-66-8
Purity	>98%
MWt	428.50
Formula	C22H24N2O5S
Solubility	DMSO : 50 mg/mL (116.69 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Membrane Transporter/Ion Channel
Target	Chloride Channel
Biological Activity	Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity^[1]. In Vitro: Eact elicits both itch-and pain- related behaviours in a TRPV1-dependent manner. Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner with an EC₅₀ of 11.6 +/- 2.5 uM. TMEM16A activator Eact activates both native and recombinant TRPV1 channels^[1].
Research Area	Neurological Disease

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