U18666A

3039-71-2

C25H42ClNO2

DMSO : 50 mg/mL (117.91 mM; Need ultrasonic); H2O : 10 mg/mL (23.58 mM; Need ultrasonic)

Others

U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. IC50 & Target: Cholesterol^[1][2]. In Vitro: U18666A, the antiviral effect is found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppresse de novo sterol biosynthesis in treated infected cells. It is also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggesting dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication^[1][2].