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Fumonisin B1

Fumonisin B1

Item no.	CS-0029116-1mg
Manufacturer	ChemScene
Amount	1mg
Category	Food Safety Mycotoxins Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	116355-83-0
Similar products	116355-83-0
Available
CAS	116355-83-0
Purity	>98%
MWt	721.83
Formula	C34H59NO15
Solubility	H₂O : 16.67 mg/mL (ultrasonic)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Acyltransferase
Biological Activity	Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin^[1]^[2]. IC50 & Target: Sphingosine N-acyltransferase^[2] In Vitro: Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells^[3]. Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes^[3].
Research Area	Infection

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