TBCA

Item no.	CS-0032876-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	934358-00-6
Similar products	934358-00-6
Available
CAS	934358-00-6
Purity	>98%
MWt	463.74
Formula	C9H4Br4O2
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Stem Cell/Wnt; Cell Cycle/DNA Damage
Target	Casein Kinase; Casein Kinase
Biological Activity	TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC₅₀ of 110 nM and a K_i of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases^[1]^[2]. In Vitro: TBCA (0-100 uM; 24 hours) shows a drastic effect on Jurkat cells viability^[1]. TBCA also inhibits CK2 double mutant (Val66 Ile174) with an IC₅₀ of 0.68 uM^[1]. TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3beta induced by AYPGKF^[2].
Research Area	Cancer

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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