ASP2535

374886-51-8

382.42

10 mM in DMSO

Neuronal Signaling; Membrane Transporter/Ion Channel

ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease^[1]. IC50 & Target: GlyT1^[1] In Vitro: ASP2535 potently inhibits rat GlyT1 (IC₅₀=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro^[1].
In Vivo: ASP2535 (0.3-3 mg/kg; p.o) attenuates working memory deficit in MK-801-treated mice and visual learning deficit in neonatally phencyclidine (PCP)-treated mice^[1].
ASP2535 (1-3 mg/kg, p.o.) also improves the PCP-induced deficit in prepulse inhibition in rats^[1].