Parbendazole

14255-87-9

C13H17N3O2

H2O : < 0.1 mg/mL (insoluble); DMSO : 4 mg/mL (16.18 mM; Need ultrasonic)

Cell Cycle/DNA Damage; Cytoskeleton

Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC₅₀ of 8.79?nM, and exhibits a broad-spectrum anthelmintic activity. IC50 & Target: EC50: 8.79?nM (tubulin)^[1] In Vitro: Parbendazole is a tubulin destabilizer, with an EC₅₀ of 8.79?nM, and can induce DNA damage^[1]. Parbendazole (2-10 uM) inhibits the assembly of microtubules dose-dependently, with an IC₅₀ of 3 uM. Parbendazole (2-20 uM)-treated cells show an complete absence of microtubules in Vero cells^[2]. Parbendazole (up to 10 uM) inhibits the growth of CLd-AXE myxamoebae. Parbendazole (2-5 uM) potently inhibits tubulin purified from the wild-type myxamoebae^[3].