dTRIM24

2170695-14-2

C55H68N8O13S2

Ethanol : < 1 mg/mL (insoluble)

Epigenetics; PROTAC

dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC. IC50 & Target: TRIM24^[2]. In Vitro: dTRIM24 is a degrader of TRIM24 bromodomain. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. The anti-proliferative consequences of chemical degradation versus inhibition of TRIM24 are assessed. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. In agreement with a sustained proliferative defect observed following dTRIM24 treatment, near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment^[2].