O-304

1261289-04-6

C16H11Cl2N3O2S

DMSO : 30 mg/mL (78.90 mM; Need ultrasonic and warming)

Epigenetics; PI3K/Akt/mTOR

O-304 is a small molecule AMPK activator. IC50 & Target: AMPK^[1] In Vivo: O-304 efficiently increases glucose uptake and reduces insulin resistance in skeletal muscle a primary cause of obesity-induced T2D. O-304 also reverses beta-cell stress/dysfunction and induce beta-cell rest. O-304 also increases energy expenditure and protects against diet induced obesity, fatty liver, hyperlipidemia and diabetes. CVD remains a major cause of death of T2 diabetics, and O-304 increases peripheral blood flow and left ventricular function, and acts as an "Exercise mimetic". Thus, as an AMPK activator O-304 uniquely mitigates many of the metabolic and cardiovascular complications associated with the obesity epidemic. O-304 has the unique potential to increase glucose uptake and reduce insulin resistance in newly diagnosed T2 diabetics and as such prevent the associated beta-cell hyperactivity/failure and progression of the disease^[1].