Angiotensin III, human, mouse

13602-53-4

931.09

H2O : 100 mg/mL (107.40 mM; Need ultrasonic)

GPCR/G Protein

Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively. IC50 & Target: IC50: 0.648 nM (AT₂R), 21.1 nM (AT₁R)^[1] In Vitro: Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively^[1]. In Vivo: Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (U_NaV), fractional excretion of sodium (FE_Na), and fractional excretion of lithium (FE_Li) in SD rat^[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats^[3].