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Anserine

Anserine

Manufacturer	ChemScene
Category	Food Safety Reagents & Chemicals Molecules Amino Acid Analysis
Type	Molecules
Specific against	other
Amount	10g
Item no.	CS-0062279-10g
CASRN	584-85-0
eClass 6.1	32169090
eClass 9.0	32169090
Available
CAS	584-85-0
Purity	>98%
MWt	240.26
Formula	C10H16N4O3
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Endogenous Metabolite
Biological Activity	Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice^[1]^[2]. In Vivo: Anserine (drinking water at a concentration of 2.0?g/L (equivalent to 10?mg/mouse); for 8 weeks) completely recoveres the memory deficits, improves pericyte coverage on endothelial cells in the brain, and diminishes chronic glial neuroinflammatory reactions in AbetaPPswe/PSEN1dE9 Alzheimer's disease (AD) model mice over 18-months old^[2].
Research Area	Neurological Disease

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Delivery expected until 7/4/2024