Glucagon-like peptide 1 (1-37), human (TFA)

HuGLP-1 (TFA)

4283.50

10 mM in H2O

GPCR/G Protein

Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor. IC50 & Target: GLP-1 receptor^[1]. In Vitro: Glucagon-like peptide-1 (GLP-1) is produced by the posttranslational processing of proglucagon and acts as a regulator of various homeostatic events. GLP-1(1-37) is more stable than GLP-1(7-37), with 94.7% of the initial amount of peptide left after a 4h exposure to mouse serum. GLP-1(1-37) is confirmed to be a highly potent agonist of the GLP-1 receptor (GLP-1R) by measuring the expression of the luciferase reporter gene expression in transiently transfected human embryonic kidney (HEK293) cells^[1]. In Vivo: GLP-1(1-37) decreases glycemic excursion in a dose-dependent. The administration of GLP-1(1-37) or GLP-1(7-37) markedly decrease blood glucose levels at 15 min and 30 min compared with the control group^[1].