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CCR2 antagonist 1

CCR2 antagonist 1

Item no.	CS-0064618-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Metabolism Cholesterol & Lipid Metabolism Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1683534-96-4
Similar products	1683534-96-4
Available
CAS	1683534-96-4
Purity	>98%
MWt	549.47
Formula	C28H32BrF3N2O
Solubility	DMSO : 125 mg/mL (227.49 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Immunology/Inflammation; GPCR/G Protein
Target	CCR; CCR
Biological Activity	CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a K_i of 2.4 nM. IC50 & Target: Ki: 2.4 nM (CCR2)^[1]. In Vitro: The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), K_i=2.4 nM; RT=714 min)^[1].
Research Area	Endocrinology

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Amount: 50mg

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