Comparison

ML753286

Item no. CS-0065641-1mg
Manufacturer ChemScene
Amount 1mg
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Alias 1699720-89-2
Similar products 1699720-89-2
Available
CAS
1699720-89-2
Purity
>98%
MWt
355.43
Formula
C20H25N3O3
Solubility
10 mM in DMSO
Clinical Information
No Development Reported
Pathway
Membrane Transporter/Ion Channel
Target
BCRP
Biological Activity
ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 uM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species[1]. IC50 & Target: IC50: 0.6 uM (BCRP)[1] In Vitro: ML753286 has IC50 values of >30, 0.6, and 39.0 uM for the inhibition of P-gp-, BCRP-, and OATP mediated transport, respectively[1]. In Vivo: ML753286 (25- or 50-mg/kg (PO); 10 or 20 mg/kg (IV); 0.083-24 hours) appears to completely inhibit Bcrp functions in rats at 25 mg/kg PO or at 20 mg/kg IV. The tmax values in plasma were 1.4, 4.0, and 4.1 hours in Bcrp KO rats, WT rats pre-administered 25-mg/kg ML753286, and WT rats pre-administered 50-mg/kg ML753286, respectively[1].
Research Area
Cancer

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1mg
Available: In stock
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