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Lotilaner

Lotilaner

Item no.	CS-0065903-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1369852-71-0
Similar products	1369852-71-0
Available
CAS	1369852-71-0
Purity	>98%
MWt	596.76
Formula	C20H14Cl3F6N3O3S
Solubility	DMSO : >= 150 mg/mL (251.36 mM)
Clinical Information	No Development Reported
Pathway	Neuronal Signaling; Membrane Transporter/Ion Channel; Anti-infection
Target	GABA Receptor; GABA Receptor; Parasite
Biological Activity	Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC₅₀ of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor^[1]. IC50 & Target: IC50: 23.84 nM (DmS-GABA), 38.25 nM (DmR2-GABA), 52.40 nM (Ls-GABA1), 36.79 nM (Rm-GABA)^[1] In Vitro: Lotilaner shows IC₅₀s of 38.25 +/- 3.75, 52.40 +/- 4.54, 36.79 +/- 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively^[1].
Research Area	Infection

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Amount: 50mg

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