Asp-AMS

828288-98-8

C14H19N7O9S

DMSO : >= 100 mg/mL (216.73 mM)

Metabolic Enzyme/Protease; Metabolic Enzyme/Protease

Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme. IC50 & Target: Aspartyl-tRNA synthetase, Mitochondrial enzyme ^[1]. In Vitro: Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with K_i in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with K_i values in the nanomolar range, with a stronger effect on bacterial AspRSs (E. coli and P. aeruginosa) than on human cytosolic AspRS^[1].