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Foliglurax (monohydrochloride)

Foliglurax (monohydrochloride)

Item no.	CS-0068027-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Neuroscience Molecular Targets for Neuroscience Neural Signaling Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	2133294-96-7
Available
Alternative Names	PXT002331 (monohydrochloride)
CAS	2133294-96-7
Purity	>98%
Formula	C23H24ClN3O3S
MWt	457.97
Solubility	DMSO : 5 mg/mL (10.92 mM; Need ultrasonic)
Clinical Information	Phase 2
Pathway	GPCR/G Protein; Neuronal Signaling
Target	mGluR; mGluR
Biological Activity	Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC₅₀ of 79 nM^[1]. Antiparkinsonian effect^[1]. In Vitro: Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders^[2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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