MS402

Item no.	CS-0068835-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1672684-68-2
Similar products	1672684-68-2
Available
CAS	1672684-68-2
Purity	>98%
MWt	370.83
Formula	C20H19ClN2O3
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Epigenetics
Target	Epigenetic Reader Domain
Biological Activity	MS402 is a BD1-selective BET BrD inhibitor with K_is of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice^[1]. In Vivo: Reconstitution with naïve CD4⁺CD45RB^hi cells isolated from spleen and lymph nodes of C57BL/6 mice, Rag1^-/- mice begin losing weight after 4 week. MS402 (10 mg/kg; intraperitoneally twice a week for 3 weeks) shows much less weight loss^[1].
Research Area	Cancer; Inflammation/Immunology

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