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TM-25659

TM-25659

Item no.	CS-0069266-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	260553-97-7
Available
CAS	260553-97-7
Purity	>98%
Formula	C30H28N8
MWt	500.60
Solubility	H2O : < 0.1 mg/mL (insoluble); DMSO : >= 135 mg/mL (269.68 mM)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	TM-25659 is a transcriptional co-activator with PDZ-binding motif (TAZ) modulator. Anti-osteoporotic and anti-obesity activities^[1]. IC50 & Target: TAZ^[1] In Vitro: TM-25659 (2, 10, 20, 100 uM) enhances nuclear TAZ localization in a dose-dependent manner and attenuates PPARgamma-mediated adipocyte differentiation by facilitating PPARgamma suppression activity of TAZ^[1]. TM-25659 (2, 10, 50 uM) enhances osteogenic gene expression and thereby increases osteoblast differentiation^[1]. In Vivo: TM-25659 (50 mg/kg, i.p., every other day for 2 weeks) suppresses bone loss in vivo and decreases weight gain in an obesity model^[1]. TM-25659 has a favourable pharmacokinetic profile in rats. The plasma concentration of TM-25659 declines with an approximate t_1/2 of 7 or 10 h following i.v or p.o. administration respectively. The systemic clearance (CL) is 0.21 Lxh^-1xkg^-1 and the volume of distribution at steady-state (1.91 Lxh^-1xkg^-1) is larger than the volume of total body fluids^[1].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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