2-D08

Item no.	CS-0077855-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	144707-18-6
Available
CAS	144707-18-6
Purity	>98%
Formula	C15H10O5
MWt	270.24
Solubility	DMSO : 150 mg/mL (555.06 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Target	E1/E2/E3 Enzyme; TAM Receptor
Biological Activity	2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC₅₀ of 0.49 nM. IC50 & Target: IC50: 0.49 nM (Axl)^[2] In Vitro: 2-D08 inhibits sumoylation by preventing transfer of SUMO from the UBC9-SUMO thioester to the substrate^[1]. 2-D08 decreases the ratio of p-Axl to t-Axl in a dose-dependent manner. Suppression of Axl kinase activity by 2D08 disrupts the cytoskeleton and actin filaments with re-organization at cellular junctions^[2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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