MSAB

173436-66-3

305.35

DMSO : 250 mg/mL (818.73 mM; Need ultrasonic)

Stem Cell/Wnt; Stem Cell/Wnt

MSAB is a potent and selective inhibitor of Wnt/beta-catenin signaling. MSAB binds to beta-catenin promoting its degradation, and specifically downregulates Wnt/beta-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells^[1]. IC50 & Target: Wnt/beta-catenin^[1] In Vitro: MSAB (2-10 uM) selectively decreases cell viability of Wnt-dependent cells while showing little effect on Wnt-independent cells and normal human cells^[1].
MSAB (0.01-10 uM; 20 h) inhibits T-cell factor (TCF) luciferase reporter activity in HCT116 cells^[1].
MSAB (20 h) suppresses the Wnt3a-induced TOP-Luc activation and increases of active beta-catenin levels in HEK293T cells^[1].
MSAB (0.5-10 uM; 20 h) decreases mRNA and protein levels of endogenous Wnt target genes in HCT116 cells^[1].
MSAB (5 uM; 16 h) induces degradation of beta-catenin in a proteasome-dependent manner in HCT116 cells^[1]. In Vivo: MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model^[1].
MSAB (10-20 mg/kg; i.p. twice daily for 2 weeks) inhibits tumor growth of MMTV-Wnt1 transgenic mice^[1].