RIPK1-IN-7

2300982-44-7

C25H22F3N5O2

H2O : < 0.1 mg/mL (insoluble); DMSO : 62.5 mg/mL (129.81 mM; Need ultrasonic)

Apoptosis

RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a K_d of 4 nM and an enzymatic IC₅₀ of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model^[1]. IC50 & Target: IC50: 11 nM (RIPK1)^[1]
Kd: 4 nM (RIPK1)^[1] In Vitro: RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC₅₀ of 2nM^[1].
RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC₅₀s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively^[1].