« Back
Home /
GLPG2451

GLPG2451

Item no.	CS-0078808-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2055015-61-5
Similar products	2055015-61-5
Available
CAS	2055015-61-5
Purity	>98%
MWt	419.38
Formula	C16H16F3N3O5S
Solubility	DMSO : 270 mg/mL (643.81 mM; Need ultrasonic)
Clinical Information	Phase 1
Pathway	Autophagy; Membrane Transporter/Ion Channel
Target	Autophagy; CFTR
Biological Activity	GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC₅₀ of 11.1 nM^[1]. IC50 & Target: Cystic fibrosis transmembrane conductance regulator^[1] In Vitro: GLPG2451 has an EC₅₀ value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells^[1].
Research Area	Inflammation/Immunology

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50mg

available

Delivery expected until 10/2/2025

Express Delivery: Save 16 days

Compare

Add to wishlist

Get an offer