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Bevantolol (hydrochloride)

Bevantolol (hydrochloride)

Item no.	CS-0080735-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	42864-78-8
Similar products	42864-78-8
Available
CAS	42864-78-8
Purity	>98%
MWt	381.89
Formula	C20H28ClNO4
Solubility	DMSO : 62.5 mg/mL (163.66 mM; Need ultrasonic)
Clinical Information	Launched
Pathway	Membrane Transporter/Ion Channel; GPCR/G Protein; Neuronal Signaling; Neuronal Signaling
Target	Calcium Channel; Adrenergic Receptor; Calcium Channel; Adrenergic Receptor
Biological Activity	Bevantolol hydrochloride is a selective beta1 and alpha1-adrenergic receptor antagonist with pK_i values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca²⁺ antagonist^[1]^[2]. IC50 & Target: pKi: 7.83 (beta1-adrenergic receptor), 6.9 (alpha1-adrenergic receptor), 6.23 (beta2-adrenergic receptor) and Ca²⁺^[1]^[2] In Vitro: Bevantolol hydrochloride has a pK_i of 6.23 for beta2-adrenergic receptor^[1]. In Vivo: Bevantolol hydrochloride (200 mg/kg; PO by water; for 6 weeks) produces a significant decrease in the expression level of beta1 adrenoceptor mRNA^[2].
Research Area	Metabolic Disease; Neurological Disease

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Amount: 100mg

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