A1874

Item no.	CS-0082007-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	2064292-12-0
Available
CAS	2064292-12-0
Purity	>98%
Formula	C58H62Cl3F2N9O7S
MWt	1173.59
Solubility	H2O : < 0.1 mg/mL (insoluble); DMSO : 150 mg/mL (127.81 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Epigenetics; PROTAC
Target	Epigenetic Reader Domain; PROTAC
Biological Activity	A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC₅₀ of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation^[1]. IC50 & Target: DC50: 32 nM (induce BRD4 degradation in cells)^[1]. In Vitro: Treatment of HCT116 cells of A1874 (0-10 uM, 24 hours) induces a dose-dependent knockdown of BRD4 levels, with near-maximum knockdown by 100 nmol/L and a maximum degradation (Dmax) of BRD4 of 98% of the levels in control (0.1% DMSO-treated) cells^[1]. Treatment of HCT116 cells of A1874 (0-10 uM, 24 hours) increases p53 levels in the HCT116 cells and showed dose-dependent p53 stabilization^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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