S-Nitroso-N-acetyl-DL-penicillamine

67776-06-1

220.25

DMSO : 250 mg/mL (1135.07 mM; Need ultrasonic)

Immunology/Inflammation

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation^[1][2][3][4]. In Vitro: S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO)^[1].
S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes^[3].
S-Nitroso-N-acetyl-DL-penicillamine (100 uM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes^[3].
In Vivo: SNAP (100uM, 300uM) causes small but significant increases of the electrically evoked [³H]-acetylcholine release in guinea-pig tracheal^[4].