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CDK5 inhibitor 20-223

CDK5 inhibitor 20-223

Item no.	CS-0085638-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Neuroscience Molecular Targets for Neuroscience Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	865317-30-2
Similar products	865317-30-2
Available
CAS	865317-30-2
Purity	>98%
MWt	305.37
Formula	C19H19N3O
Solubility	DMSO : 100 mg/mL (327.47 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Cell Cycle/DNA Damage
Target	CDK
Biological Activity	CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC₅₀s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent^[1]. In Vitro: CDK5 inhibitor 20-223 (10 nM-10 uM; 72 hours) potently inhibits cell growth in a panel of colorectal cancer (CRC) cell lines^[1]. CDK5 inhibitor 20-223 (0.3125-20 uM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in each of the three CRC cell lines^[1]. In Vivo: CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice^[1].
Research Area	Cancer

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mg

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