MT-802

Item no.	CS-0087045-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2231744-29-7
Similar products	2231744-29-7
Available
CAS	2231744-29-7
Purity	>98%
MWt	787.82
Formula	C41H41N9O8
Solubility	DMSO : 100 mg/mL (126.93 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Protein Tyrosine Kinase/RTK; PROTAC
Target	Btk; PROTAC
Biological Activity	MT-802 is a potent BTK degrader based on PROTAC technology, with a DC₅₀ of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)^[1]. IC50 & Target: DC50: 1 nM (BTK)^[1]. In Vitro: MT-802 degrades BTK with a DC₅₀ of 9.1 nM with maximal degradation being observed by 250 nM^[1].
Research Area	Cancer; Inflammation/Immunology

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