« Back
Home /
GPI-1046

GPI-1046

Item no.	CS-0087142-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	186452-09-5
Similar products	186452-09-5
Available
CAS	186452-09-5
Purity	>98%
MWt	360.45
Formula	C20H28N2O4
Solubility	DMSO : >= 100 mg/mL (277.43 mM)
Clinical Information	No Development Reported
Pathway	Anti-infection; Immunology/Inflammation; Apoptosis; Autophagy
Target	HIV; FKBP; FKBP; FKBP
Biological Activity	GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models^[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models^[2]. GPI-1046 improves HIV-associated injury of peripheral nerves^[3]. IC50 & Target: GLT1^[1]
Research Area	Infection; Neurological Disease

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10mg

available

Delivery expected until 7/3/2025

Express Delivery: Save 17 days

Compare

Add to wishlist

Recommend by mail