WJ460

Item no.	CS-0087181-25mg
Manufacturer	ChemScene
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1415251-36-3
Similar products	1415251-36-3
Available
CAS	1415251-36-3
Purity	>98%
MWt	460.59
Formula	C27H28N2O3S
Solubility	DMSO : 250 mg/mL (542.78 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	WJ460 is a potent myoferlin (MYOF) inhibitor, which interacts directly with MYOF and exerts anti-metastatic activity in the nanomolar range in breast cancer cells^[1]. IC50 & Target: MYOF^[1] In Vitro: WJ460 blocks breast cancer cell invasion with IC₅₀ values of 43.37?+/-?3.42?nM in MDA-MB-231 and 36.40?+/-?4.51?nM in BT549 cells. WJ460 treatment remarkably inhibits MDA-MB-231 and BT549 cell invasion through Collagen I in a dose-dependent manner^[1]. In Vivo: WJ460 inhibits breast tumor growth, angiogenesis, and spontaneous metastasis in a spontaneous metastasis model^[1].
Research Area	Cancer

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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