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LIT-001

LIT-001

Item no.	CS-0087519-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2245072-21-1
Similar products	2245072-21-1
Available
CAS	2245072-21-1
Purity	>98%
MWt	645.70
Formula	C30H34F3N7O4S
Solubility	DMSO : 250 mg/mL (387.18 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	GPCR/G Protein
Target	Oxytocin Receptor
Biological Activity	LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC₅₀=55 nM; K_i=226 nM). LIT-001 improves social interaction in a mouse model of autism^[1]. IC50 & Target: EC50: 55 nM (OT-R)^[1] Ki: 226 nM (OT-R)^[1] In Vitro: In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only^[1]. In Vivo: LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )^[1].
Research Area	Neurological Disease

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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