RTC-5

Item no.	CS-0087637-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1423077-49-9
Similar products	1423077-49-9
Available
Alternative Names	TRC-382
CAS	1423077-49-9
Purity	>98%
MWt	510.96
Formula	C24H22ClF3N2O3S
Solubility	DMSO : 15 mg/mL (29.36 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Target	EGFR; EGFR
Biological Activity	RTC-5 (TRC-382) is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling^[1]. IC50 & Target: IC50: EGFR^[1] In Vitro: RTC-5 (0-40 uM; 48 hours) inhibits H1650 lung adenocarcinoma cell growth with an GI₅₀ of 12.6uM^[1]. RTC-5 (20-40 uM; 24 hours) negatively regulates PI3K-AKT and RAS-ERK pathways by decreasing phospho-AKT and phospho-ERK levels expression^[1].
Research Area	Cancer

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