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AZ12601011

AZ12601011

Item no.	CS-0090034-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Purity	>98%
MWt	313.36
Formula	C19H15N5
Solubility	DMSO : 5 mg/mL (15.96 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	TGF-beta/Smad
Target	TGF-beta Receptor
Biological Activity	AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC₅₀ of 18 nM and a K_d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth ^[1]. In Vitro: AZ12601011 (0.01-10 uM; for 20 minutes) completely inhibits Phosphorylation of SMAD2 ^[1]. AZ12601011 (0.01 uM-10 uM) inhibits the activity of ALK4, ALK7 and TGFBR1 ^[1]. AZ12601011 inhibits 4T1 cells growth in vitro (IC₅₀=0.4uM) ^[1]. In Vivo: AZ12601011 (50mg/kg; oral gavage; twice daily; for 25 days) inhibits tumour growth and metastasis in vivo^[1].
Research Area	Cancer

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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