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JAK/HDAC-IN-1

JAK/HDAC-IN-1

Item no.	CS-0090778-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2284621-75-4
Similar products	2284621-75-4
Available
CAS	2284621-75-4
Purity	>98%
MWt	450.32
Formula	C19H21Cl2N7O2
Solubility	DMSO : 20.83 mg/mL (46.26 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Epigenetics; Stem Cell/Wnt; JAK/STAT Signaling; Epigenetics; Cell Cycle/DNA Damage
Target	JAK; JAK; JAK; HDAC; HDAC
Biological Activity	JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC₅₀s of 4 and 2 nM for JAK2 and HDAC, respectively^[1]. In Vitro: JAK/HDAC-IN-1 (Compound 8m) exhibits IC₅₀s of 4.8, 7.4 and 49 nM for JAK1, JAK3 and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively^[1].
Research Area	Cancer

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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