NP-G2-044

1807454-59-6

399.37

DMSO : 100 mg/mL (250.39 mM; Need ultrasonic)

Others

NP-G2-044 is a potent, orally active fascin inhibitor, with an IC₅₀ of ca.2 uM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response^[1][2]. In Vitro: NP-G2-044 inhibits the migration of MDA-MB-231 tumor cells with an IC₅₀ ca.10 uM. NP-G2-044 decreases filopodial formation resulting in decreased lamellipodial formation^[1]. In Vivo: NP-G2-044 (100 mg/kg; i.p.; daily for 18 days) inhibits breast tumor metastasis in mouse models^[1].
Upon oral administration, NP-G2-044 targets and binds to fascin, thereby preventing the interaction of fascin with actin filaments, thereby preventing actin bundling and filopodia formation. By preventing actin cytoskeletal reorganization, the dynamic changes in cell shape that are necessary for tumor cell migration and invasion to occur are impaired, and tumor cell migration and metastasis are inhibited^[3].