BT18

Item no.	CS-0094727-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	924811-53-0
Similar products	924811-53-0
Available
CAS	924811-53-0
Purity	>98%
MWt	637.64
Formula	C30H31F4N3O6S
Solubility	DMSO : 100 mg/mL (156.83 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)^[1]. BT18 shows an effect on GDNF family receptor GFRalpha1 and RET receptor tyrosine kinase RetA function^[2]. In Vitro: BT18 (50 uM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines^[1]. BT18 (1-50 uM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines^[1]. BT18 (5-50 uM; 15 mimutes) appears to phosphorylate RET in concentration of 50 uM both in GFP-transfected and in GFRD1-transfected cells^[1].
Research Area	Neurological Disease

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Amount: 10mg

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