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DMT1 blocker 2

DMT1 blocker 2

Item no.	CS-0101643-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1062648-63-8
Similar products	1062648-63-8
Available
CAS	1062648-63-8
Purity	>98%
MWt	263.29
Formula	C16H13N3O
Solubility	DMSO : 50 mg/mL (ultrasonic)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC₅₀ of 0.83 uM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo^[1]. IC50 & Target: IC50: 0.83 uM (divalent metal transporter 1)^[1] In Vitro: DMT1 blocker 2 (Compound 12f) (10 uM; 24 h) has no cytotoxic to HepG2 cells^[1]. DMT1 blocker 2 (10 uM) inhibits 44% of CYP3A4 activity^[1]. In Vivo: DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption^[1].
Research Area	Metabolic Disease

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Amount: 50mg

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