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LY3154207

LY3154207

Item no.	CS-0105102-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1638667-79-4
Similar products	1638667-79-4
Available
CAS	1638667-79-4
Purity	>98%
MWt	450.40
Formula	C24H29Cl2NO3
Solubility	DMSO : 110 mg/mL (244.23 mM; Need ultrasonic)
Clinical Information	Phase 2
Pathway	GPCR/G Protein; Neuronal Signaling
Target	Dopamine Receptor; Dopamine Receptor
Biological Activity	LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC₅₀=3 nM)^[1]. IC50 & Target: EC50: 3 nM (human dopamine D1 receptor)^[1] In Vitro: In HEK293 cells transiently expressing human, dog, rhesus monkey, and mouse D1 receptors, the EC₅₀s of LY3154207 are 2.3 nM, 2.0 nM, 2.5 nM, and 62.1 nM, respectively^[1].
Research Area	Neurological Disease

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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