Orexin A (human, rat, mouse) (TFA)

3675.12

10 mM in DMSO

GPCR/G Protein; Neuronal Signaling

Orexin A human, rat, mouse TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse TFA has a role in the regulation of feeding behavior. Orexin A human, rat, mouse TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats^[1][2]. In Vitro: Orexin A human, rat, mouse TFA has high affinity for OX1R, with 38 nM IC₅₀ and 34 nM EC₅₀ values in the the [Ca^2?]i transient assay^[1]. In Vivo: Orexin A human, rat, mouse TFA (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8+/-2.0 s in vehicle-treated mice to 35.0+/-3.7 s and 45.7+/-4.5 s, respectively^[2].
Orexin A human, rat, mouse TFA (3, 10 and 30 mg/kg; i.v.) is given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4+/-35.2 s in vehicle-treated mice to 500.3+/-31.2 s at 10 mg/kg and 594.5+/-5.5 s at 30 mg/kg^[2].